suspension for injections
Description
Opaque light yellow liquid.
Composition
1 ml of the drug contains:
active ingredient: cefquinome sulfate – 29.64 mg;
Excipients: colza oil, propylparahydroxybenzoate, methylparahydroxybenzoate.
suspension for injections
Description
Opaque light yellow liquid.
Composition
1 ml of the drug contains:
active ingredient: cefquinome sulfate – 29.64 mg;
Excipients: colza oil, propylparahydroxybenzoate, methylparahydroxybenzoate.
Pharmacological properties
АТСvet: QJ01 - antibacterials for systemic use. QJ01DE90 — Cefquinome.
Cefquinome is the fourth generation cephalosporin, , with a broad spectrum of antibacterial action against most gram-positive and gram-negative bacteria, particularly, including but not limited to Escherichia coli, Enterobacter spp., Staphylococcus aureus, Streptococcus spp., Clostridium spp., Actinobacillus spp., Citrobacter spp., Klebsiella spp., Pasteurella spp., Proteus spp., Salmonella spp., Serratia marcescens, Histophilus somni, Arcanobacterium pyogenes, Bacillus spp., Corynebacterium spp., Bacteroides spp., Fusobacterium spp., Prevotella spp. and Erysipelothrix rhusiopathiae, as well as against β-lactamase producing strains. The drug bactericidal action mechanism is to inhibit the cell membrane synthesis of microorganisms.
After parenteral administration, cefquinome penetrates into systemic circulation, reaching its maximum concentration in blood serum in 60-90 minutes in cattle and 15-60 minutes in pigs and maintained at therapeutic level for 24 hours. The level of cefquinome binding with blood serum proteins does not exceed 5 %, it is relatively easy excreted (half-life period makes 2-2.5 hours in cattle and 9 hours in swine), primarily unchanged, in urine.
Administration
Cattle: treatment of animals against panaritium, hoof sole ulcer, purulent pododermatitis, septicemia, bacterial interdigital dermatitis, necrobacillosis and acute mastitis (including mastitis caused by Escherichia coli), escherichiosis (colibacillosis), respiratory diseases caused by Pasteurella multocida, P. haemolytica and other cefquinome-sensitive microorganisms.
Swine: treatment of animals against MMA (mastitis-metritis-agalactia) syndrome, meningitis, arthritis, dermatitis, as well as diseases of respiratory organs caused by Pasteurella multocida, Haemophillus parasuis, Actinobacillus pleuropneumoniae, Streptococcus suis and other cefquinome-sensitive bacteria.
Dosage
The drug is administered deep intramuscularly once daily in the following doses:
Animal species | Indication | Daily drug dose (per 10 kg body weight) | Period of treatment |
Cattle | Diseases of respiratory organs, interdigital necrobacillosis or dermatitis | 0.4 ml | 3–5 days |
Acute mastitis | 0.4 ml | 2 days | |
Escherichiosis (colibacillosis) in calves | 0.8 ml | 3–5 days | |
Swine | Diseases of respiratory organs | 0.8 ml | 3 days |
MMA syndrome | 0.8 ml | 2 days | |
Meningitis, arthritis, dermatitis | 0.8 ml | 5 days |
Contraindications
Do not administer to animals sensitive to the drug and other β-lactam antibiotics. Do not prescribe in combination with bacteriostatics.
Precautions
Shake the vial intensely before every use. It is recommended that the injection site be changed throughout the treatment period to prevent local reaction. Do not omit regular drug administration as it may decrease therapeutic efficacy. In case a single dose is omitted, make injection as soon as possible with subsequent intervals between injections being unchanged.
Animal slaughter for meat is possible in 8 days (cattle) and 4 days (swine) following the last administration of the drug. Milk may be consumed in 3 days following the last administration of the drug. Meat and milk obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.
Packaging
Glass vials of 50 and 100 ml sealed with rubber stoppers and aluminum caps.
Storage
Store in a dark place out of the reach of children at 2-30 °С.
Shelf life
2 years.
Use the drug within 28 days following the initial sampling from the vial provided it is stored in a dry, dark place at 2-8 С.
For veterinary use only!