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MASTILEK®

Intracesternal
MASTILEK®
Active substances:

suspension for intracisternal administration

Description

Yellow suspension.

Composition

10 ml of the drug (1 syringe tube) contains:

active ingredients: cefquinome (equivalent to cefquinome sulfate) – 75 mg; prednisolone – 10 mg;

excipient - sunflower oil.

suspension for intracisternal administration

Description

Yellow suspension.

Composition

10 ml of the drug (1 syringe tube) contains:

active ingredients: cefquinome (equivalent to cefquinome sulfate) – 75 mg; prednisolone – 10 mg;

excipient - sunflower oil.

Pharmacological properties

АТС vet QJ51 — antibacterials for systemic use. Antibacterials for intracisternal use, other beta-lactam antibacterials for intracisternal use. Cephalosporin of the 4th generation. QJ51DE90 — cefquinome.

Cefquinome is the fourth generation cephalosporin, , with a broad spectrum of antibacterial action against most gram-positive and gram-negative bacteria (Escherichia coli, Enterobacter spp., Staphylococcus aureus, Streptococcus spp., Clostridium spp., Actinobacillus spp., Citrobacter spp., Klebsiella spp., Pasteurella spp., Proteus spp., Salmonella spp., Serratia marcescens, Histophilus somni, Arcanobacterium pyogenes, Bacillus spp., Corynebacterium spp., Bacteroides spp., Fusobacterium spp., Prevotella spp. and Erysipelothrix rhusiopathiae, as well as against  β-lactamase producing strains. The drug bactericidal action mechanism is to inhibit the cell membrane synthesis of microorganisms.

Prednisolone is a synthetic glucocorticoid drug that has anti-inflammatory, anti-allergic, immunosuppressive and antiproliferative effects

Administration

The drug is used for treatment of cattle with clinical and subclinical mastitis during lactation caused by microorganisms sensitive to drug components.

Dosage

Administer contents of a single syringe tube (10 ml) heated to the body temperature 3 times with intervals of 12 hours into the teat canal after thorough milking of the damaged quarter of mammary gland. The contents of one syringe tube are injected into the teat canal of the affected quarter of the breast, pre-milked and disinfected. After drug administration, a quarter of the breast is massaged to distribute it evenly throughout the cistern. The procedure is repeated three times with an interval of 12 hours.

Contraindications

Administration of the drug to cows with hypersensitivity to cephalosporins and other β-lactam antibiotics, particularly – cefquinome, is prohibited. Withdraw and conduct symptomatic therapy in case allergic reactions are observed. Avoid increase of intervals between administrations as this may cause decreased treatment efficacy.

Precautions

Consumption of milk is allowed in 5 days following the last drug administration. Animal slaughter for meat is allowed in 4 days following the last administration of the drug.

Milk and meat, obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of a veterinary physician.

Packaging

Package with 20 polymer syringe tubes of 10 ml each.

Storage

Store in original packaging in a dry, dark place out of the reach of children at 2-

30 °С.

Shelf life

2 years.

For veterinary use only!